Nonsurgical female sterilization: comparison of intrauterine application of quinacrine alone or in combination with ibuprofen.

In many parts of the world, sterilization has become the leading method of fertility control (1). The need to make this procedure s impler , safer , and less expensive-and thereby more acceptable, even in countr ies with limited surgical facilities-is well recognized. Consequently, in the past three decades, various chemicals have been used to accomplish tubal occlusion through transcervical intrauterine application. Use of quinacrine pel le ts has become the most widely adopted method of nonsurgical female s ter i l izat ion, wi th more than 100,000 cases reported (2).